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Showing 1 to 12 of 3967 entries
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The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis.

Frontiers in aging neuroscience

Lovejoy DB, Guillemin GJ.
PMID: 25100994
Front Aging Neurosci. 2014 Jul 23;6:173. doi: 10.3389/fnagi.2014.00173. eCollection 2014.

Modulations of the potentially toxic transition metals iron (Fe) and copper (Cu) are implicated in the neurodegenerative process in a variety of human disease states including amyotrophic lateral sclerosis (ALS). However, the precise role played by these metals is...

Age-Related Hearing Loss and Cognitive Decline: You Haven't Heard the Half of It.

Frontiers in aging neuroscience

Hewitt D.
PMID: 28487649
Front Aging Neurosci. 2017 Apr 25;9:112. doi: 10.3389/fnagi.2017.00112. eCollection 2017.

No abstract available.

Cross-View Neuroimage Pattern Analysis in Alzheimer's Disease Staging.

Frontiers in aging neuroscience

Liu S, Cai W, Pujol S, Kikinis R, Feng DD.
PMID: 26941639
Front Aging Neurosci. 2016 Feb 23;8:23. doi: 10.3389/fnagi.2016.00023. eCollection 2016.

The research on staging of pre-symptomatic and prodromal phase of neurological disorders, e.g., Alzheimer's disease (AD), is essential for prevention of dementia. New strategies for AD staging with a focus on early detection, are demanded to optimize potential efficacy...

Progranulin Mutations Affects Brain Oscillatory Activity in Fronto-Temporal Dementia.

Frontiers in aging neuroscience

Moretti DV, Benussi L, Fostinelli S, Ciani M, Binetti G, Ghidoni R.
PMID: 26973510
Front Aging Neurosci. 2016 Feb 29;8:35. doi: 10.3389/fnagi.2016.00035. eCollection 2016.

BACKGROUND: Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal...

Perception and Cognition in the Ageing Brain: A Brief Review of the Short- and Long-Term Links between Perceptual and Cognitive Decline.

Frontiers in aging neuroscience

Roberts KL, Allen HA.
PMID: 26973514
Front Aging Neurosci. 2016 Mar 01;8:39. doi: 10.3389/fnagi.2016.00039. eCollection 2016.

Ageing is associated with declines in both perception and cognition. We review evidence for an interaction between perceptual and cognitive decline in old age. Impoverished perceptual input can increase the cognitive difficulty of tasks, while changes to cognitive strategies...

Identifying Dysfunctional Cortex: Dissociable Effects of Stroke and Aging on Resting State Dynamics in MEG and fMRI.

Frontiers in aging neuroscience

Kielar A, Deschamps T, Chu RK, Jokel R, Khatamian YB, Chen JJ, Meltzer JA.
PMID: 26973515
Front Aging Neurosci. 2016 Mar 03;8:40. doi: 10.3389/fnagi.2016.00040. eCollection 2016.

Spontaneous signals in neuroimaging data may provide information on cortical health in disease and aging, but the relative sensitivity of different approaches is unknown. In the present study, we compared different but complementary indicators of neural dynamics in resting-state...

The Role of Detraining in Tendon Mechanobiology.

Frontiers in aging neuroscience

Frizziero A, Salamanna F, Della Bella E, Vittadini F, Gasparre G, Nicoli Aldini N, Masiero S, Fini M.
PMID: 26973517
Front Aging Neurosci. 2016 Feb 29;8:43. doi: 10.3389/fnagi.2016.00043. eCollection 2016.

INTRODUCTION: Several conditions such as training, aging, estrogen deficiency and drugs could affect the biological and anatomo-physiological characteristics of the tendon. Additionally, recent preclinical and clinical studies examined the effect of detraining on tendon, showing alterations in its structure...

Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous System.

Frontiers in aging neuroscience

Capani F, Quarracino C, Caccuri R, Sica RE.
PMID: 26973519
Front Aging Neurosci. 2016 Mar 04;8:45. doi: 10.3389/fnagi.2016.00045. eCollection 2016.

Along the last years it has been demonstrated that non-neural cells play a major role in the pathogenesis of the primary degenerative disorders (PDDs) of the human central nervous system. Among them, astrocytes coordinate and participate in many different...

Electrophysiological Advances on Multiple Object Processing in Aging.

Frontiers in aging neuroscience

Mazza V, Brignani D.
PMID: 26973520
Front Aging Neurosci. 2016 Mar 02;8:46. doi: 10.3389/fnagi.2016.00046. eCollection 2016.

EEG research conducted in the past 5 years on multiple object processing has begun to define how the aging brain tracks the numerosity of the objects presented in the visual field for different goals. We review the recent EEG...

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade.

Frontiers in aging neuroscience

Kazim SF, Chuang SC, Zhao W, Wong RK, Bianchi R, Iqbal K.
PMID: 28392767
Front Aging Neurosci. 2017 Mar 24;9:71. doi: 10.3389/fnagi.2017.00071. eCollection 2017.

Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It remains unclear if network hyperexcitability precedes memory impairment in mouse models of AD and what are...

Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains.

Frontiers in aging neuroscience

Brinkmeyer-Langford CL, Guan J, Ji G, Cai JJ.
PMID: 27536236
Front Aging Neurosci. 2016 Aug 03;8:183. doi: 10.3389/fnagi.2016.00183. eCollection 2016.

Human aging is associated with cognitive decline and an increased risk of neurodegenerative disease. Our objective for this study was to evaluate potential relationships between age and variation in gene expression across different regions of the brain. We analyzed...

The Role of the Ventromedial Prefrontal Cortex in Purchase Intent Among Older Adults.

Frontiers in aging neuroscience

Koestner BP, Hedgcock W, Halfmann K, Denburg NL.
PMID: 27536238
Front Aging Neurosci. 2016 Aug 03;8:189. doi: 10.3389/fnagi.2016.00189. eCollection 2016.

Older adults are frequently the targets of scams and deception, with millions of individuals being affected each year in the United States alone. Previous research has shown that the ventromedial prefrontal cortex (vmPFC) may play a role in vulnerability...

Showing 1 to 12 of 3967 entries